It has a range of efficacies depending on the protocol used with several different treatment protocols, including the induration protocol, the minimal erythema dose protocol, and the newer minimal blistering dose protocol. THE XTRAC ® ADVANTAGE. 1984;4:201–206. Successful use of the excimer laser for generalized psoriasis in an ustekinumab non-responder. XTRAC is also endorsed by the National Psoriasis Foundation and the technology is part of the approved clinical protocols recommended by the American Academy of Dermatology. Goldberg DJ, Chwalek J, Hussain M. 308-nm excimer laser treatment of palmoplantar psoriasis. 2012 Apr;66(4):664-72. doi: 10.1016/j.jaad.2011.07.011. By accessing the work you hereby accept the Terms. When compared to the narrow band UVB laser, the 308 nm laser has an increased induction rate of T-cell apoptosis.1 Compared with traditional narrow band UV therapy, the excimer laser requires on average less number of treatment sessions and thus a smaller amount of cumulative UVB exposure. Pilot evaluation of supra-erythemogenic phototherapy with excimer laser in the treatment of patients with moderate to severe plaque psoriasis. The 308 nm excimer laser is an excellent option for the treatment of psoriasis and has been demonstrated to be effective in many different ways. UK VAT Group: GB 365 4626 36. A maintenance protocol for psoriasis plaques cleared by the 308 nm excimer laser. Arch Dermatol. This site is owned and operated by Informa PLC ( “Informa”) whose registered office is 5 Howick Place, London SW1P 1WG. The laser was an XTRAC XeCl excimer (PhotoMedex, Radnor, Pa) with output consisting of monochromatic 308-nm light with a pulse width of 30 ns and a fiberoptic delivery system connected to J Drugs Dermatol. All studies determined the initial treatment dose using either the minimal erythema dose (MED) or induration. All rights reserved. eCollection 2016. 2015;26:16–18. 2011;13:47–49. Linsker R, Srinivasan R, Wynne JJ, Alonso DR. Far-ultraviolet laser ablation of atherosclerotic lesions. Although the excimer laser is not a first-line treatment, it remains an excellent treatment option for psoriasis patients and has been demonstrated to be an effective treatment with little to no side effects. The 308 nm can also be used in the treatment of mild to moderate plaque psoriasis in children. 2012;28:184–190. This protocol identifies the minimum dose at which the patient will blister, and then subsequent treatments are administered at doses less than the MBD. 1992;23:117–133. Mudigonda T, Dabade TS, Feldman SR. A review of protocols for 308 nm excimer laser phototherapy in psoriasis. J Dermatol Treat. Because XTRAC delivers a highly targeted, therapeutic beam of UVB light only to areas of the skin affected by psoriasis, healthy skin surrounding the lesions stays that way. It means that the treatment will not work well for psoriasis cases that affect large parts of the body. Pahlajani N, Katz BJ, Lozano AM, Murphy F, Gottlieb A. A literature search on PubMed was used with combinations of the terms “excimer”, “excimer laser”, “308 nm”, “psoriasis”, “protocol”, “safety”, “efficacy”, acceptability”, “side effects”, and “dose”. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. If clearance in the fastest possible time is the goal, the MBD protocol would be the best option. 2006;22:181–183. Photodermatol Photoimmunol Photomed. COVID-19 is an emerging, rapidly evolving situation. Background: Traditionally, treatment with the excimer laser requires determining the minimal erythema dose on healthy skin or using plaque-based induration; however, these protocols often lead to underdosing of psoriatic plaques and reduced treatment efficacy. Psoriasis vulgaris compromises more than 80% of cases, usually present with raised, well-demarcated, erythematous oval plaques with adherent silvery scale. At his 1-week follow up, the patient was noted to have achieved PASI-75.17, Although there have been no studies formally evaluating patient acceptability of the excimer laser treatment, the previously mentioned safety profile for excimer laser treatment of psoriasis makes it a generally well-tolerated treatment. Mudigonda T, Dabade TS, West CE, Feldman SR. Gattu S, Pang ML, Pugashetti R, Malick F, Hong J, Bowers E, Levatter JI, Koo J. J Dermatolog Treat. There were a variety of treatment protocols that were identified for the treatment of psoriasis with the excimer laser. They investigated the use of excimer laser for treatment of 10 patients with chronic plaque psoriasis and concluded that it was an effective treatment option.15 Since its initial introduction to dermatology, use of the excimer laser as a treatment option has expanded to applications in many dermatologic diseases. The 308 nm excimer laser is a widely used device throughout the field of dermatology for many diseases, including psoriasis, vitiligo, hypopigmented disorders, alopecia areata, atopic dermatitis, and in many other dermatologic diseases such as cutaneous T-cell lymphoma, other lymphoproliferative disorders, granuloma annulare, Langerhans cell histiocytosis, lichen planus, and localized scleroderma.1,2 The term excimer is derived from “excited dimer,” which describes the mixture of the noble gas xenon and the halogen chloride gas (XeCl) that is utilized. This scalp psoriasis was refractory to topical corticosteroids and acitretin. •  Associations & Partners   Successful Use of the 308-nm Excimer Laser in Early Patch Stage Mycosis Fungoides. 2012;28:133–136. ability to treat mi ld, moderate and eve n severe but localised. Beggs S, Short J, Rengifo-Pardo M, Ehrlich A. Wong JW, Nguyen TV, Bhutani T, Koo JY. A 308-nm excimer laser for the treatment of scalp psoriasis. This demonstrated that the combination of excimer laser with alternating clobetasol spray and calcitriol ointment is a promising option and can easily be implemented in any treatment involving the excimer laser.30, In another 12-week study Levin et al treated moderate to severe psoriasis patients with twice weekly excimer treatments combined with twice daily clobetasol propionate followed by calcitriol ointment twice daily. The conclusion was that psoriasis required 7 to 11 treatment sessions to clear. From editorial acceptance to publication. Excimer lasers aim a high intensity ultraviolet B (UVB) light dose of a very specific wavelength -- 308 nanometers -- directly at the psoriasis plaques. Randomized, prospective trials are needed to establish laser therapy protocols for maintaining the plaque clearance achieved with the 308 nm excimer laser. Contact Us   Photodermatol, Photoimmunol, Photomed. Feldman SR, Mellen BG, Housman TS, et al. Although the PDL laser performed better than the excimer laser for the treatment of nail psoriasis, 38% of hands treated with the excimer laser achieved NAPSI-50, an improvement of at least 50% in nail psoriasis.39, Palmoplantar pustular psoriasis is another subtype of psoriasis that can often be difficult to treat. Several different treatment protocols have been developed and optimized to more effectively treat psoriatic lesions and to achieve greater improvements in the PASI score with fewer treatments. J Am Acad Dermatol. The excimer laser has been used successfully in patients with AA. Supraerythemogenic excimer laser in combination with clobetasol spray and calcitriol ointment for the treatment of generalized plaque psoriasis: Interim results of an open label pilot study. A tapering of laser treatments may be beneficial in maintaining the level of plaque clearance obtained from biweekly laser treatments. Available from https://www-03.ibm.com/press/us/en/pressrelease/39829.wss. It has been demonstrated that the excimer laser can be an effective treatment option even for psoriasis that has failed treatment with biologic agents. This FDA-approved method uses a … Dermatol Surg. Excimer laser works in different mechanism to reduce the excessive skin growth, thus reducing the effects of psoriasis. The major side effects identified were erythema, tenderness, and blistering at the sites of treatment. As its usage as a targeted monotherapy increases, future trials should consider evaluating and modifying these parameters to determine the most optimal management of localized psoriasis. 2020 Jul;20(1):52-55. doi: 10.3892/etm.2020.8529. NLM In this report, we present the case of a patient diagnosed with plaque psoriasis, resistant to topical ointments, successfully treated with the 308 nm excimer laser. Back to Journals » Psoriasis: Targets and Therapy » Volume 6, Authors Abrouk M, Levin E, Brodsky M, Gandy JR, Nakamura M, Zhu TH, Farahnik B, Koo J, Bhutani T, Published 12 December 2016 Number 3099067. Efficacy of the 308-nm excimer laser for treatment of psoriasis: results of a multicenter study. To characterize treatment parameters for 308 nm excimer laser phototherapy. After 5weeks, 1session per week, the condition significantly improved (Fig. This article has no funding source. Stamm, U. et al. The use of excimer laser in psoriasis was first documented in 1997 by Bonis, et al., who described the superior effects of excimer over traditional NB-UVB phototherapy in a non-randomized, left to right comparison in six patients. Our clinic is equipped with Alma’s Excimerlaser which is best device of worldwide. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. However, it is important to consider patient goals in treatment when identifying the appropriate treatment protocol. This is a discussion that should be had with patients and clinicians before treatment. The excimer laser in orthopaedics. We offer real benefits to our authors, including fast-track processing of papers. Excimer can also be used for different types of … J Dermatolog Treat. In order to provide our website visitors and registered users with a service tailored to their individual preferences we use cookies to analyse visitor traffic and personalise content. 2007;33:361–363. The excimer laser has been adopted by other medical disciplines such as cardiology, dentistry, and orthopedics.12–14. J Drugs Dermatol. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. 2003;361:1197–1204. Lebwohl M. Psoriasis. Appropriate patient selection is important when considering excimer laser treatment for psoriasis. Unlike conventional light therapies, the XTRAC excimer laser delivers a highly targeted therapeutic beam of UVB light to areas of the skin affected by psoriasis without harming the surrounding skin so you can LIVE CLEAR. Kemeny L, Bonis B, Dobozy A, Bor Z, Szabó G, Ignácz F. 308-nm excimer laser therapy for psoriasis. Plaque-based sub-blistering dosimetry: reaching PASI-75 after two treatments with 308-nm excimer laser in a generalized psoriasis patient. Tang YJ, Xu WW, Liu XM, Zhang RZ, Xu CX, Xu B, Cheng S, Liu Q. Int J Clin Exp Med. J Dermatolog Treat. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms. Treatment with the excimer laser was twice weekly, with a mean of 21 total treatments. These studies also confirm that an average of 10 treatments should clear the plaques.18–22, In addition to plaque psoriasis, the 308 nm laser is useful in the treatment of intertriginous psoriasis as demonstrated by a few case reports.23,24 Recently, split scalp studies have shown beneficial results of the laser in treating scalp psoriasis. Excimer laser treatment is highly effective in psoriasis, another T cell–mediated disorder that shares many immunologic features with AA. Over 5 million XTRAC treatments have been performed by leading dermatologists around the … Methods: A literature search on PubMed was used with combinations of the terms “excimer”, “excimer laser”, “308 nm”, “psoriasis”, “protocol”, “safety”, “efficacy”, acceptability”, “side effects”, and “dose”. Finally, alopecia areata can be treated with the 308nm excimer laser. The 308 nm excimer laser has the ability to treat mild, moderate and even severe but localised psoriasis plaques and plays an important role in the treatment management of psoriasis. this site will not function whilst javascript is disabled. Debbaneh MG, Levin E, Sanchez Rodriguez R, Leon A, Koo J, Rosenblum MD. Figure 3 Common side effects of the 308 nm excimer laser in the treatment of psoriasis. •  Privacy Policy   Photodermatol Photoimmunol Photomed. The use of higher fluencies was reported to result in higher occurrences of blistering. Manual separation of the hair was used to provide access, and starting doses ranged from 300 to 1000 mJ depending on Fitzpatrick skin type. Kagen M, Cao LY, Oyetakin-White P, Tacastacas JD, Yan C, McCormick TS, Cooper KD. It was reported that there were no side effects experienced, and the patients’ hairline remained clear during the entire duration of follow up, which was 3 months after therapy was completed.36, In a comparative study involving 13 patients with treatment refractory scalp psoriasis, the excimer laser was used for treatment in conjunction with a hair blow-dryer to help move the hair and deliver optimum laser penetration. An optimal therapeutic dose protocol with excimer laser for the treatment of plaque psoriasis yielded more effective dosing in fewer treatment sessions, … The excimer laser has been demonstrated to be an effective treatment option for psoriasis variants and locations that may be more difficult to treat with topical modalities.32, The scalp is involved in up to 80% of patients with psoriasis, and the excimer laser can be useful in the treatment of scalp psoriasis. Background: 308 nm excimer laser phototherapy is efficacious in the treatment of localized psoriasis. Fluency adjustments during the course of treatment were important to minimize phototherapy-associated side effects. Background: Future studies pertaining to the safety of the 308 nm laser in the treatment of psoriasis will presumably include continued modification of the treatment protocol to reduce the number of treatments needed for plaque resolution, while still resulting in longer periods of plaque remission. With the recent development of highly effective biologic and systemic agents, it may be difficult to justify the monotherapy of excimer laser alone in patients with moderate to severe psoriasis, but with the demonstrated efficacy in combination with topicals and the ability to improve symptoms of refractory psoriasis, the excimer laser should continue to remain an excellent treatment option. 2014;5:8–12. Bonis et al were the first to study the use of the 308 nm XeCl excimer laser in the field of dermatology in 1997. Few adverse reactions have been reported, and they are consistent with adverse reactions associated with other forms of phototherapy including erythema, blistering, hyperpigmentation, and hypopigmentation (Figure 3). J Am Acad Dermatol. Levin E, Debbaneh M, Malakouti M, et al. Pediatr Dermatol. 2006;22:181–183. Treatment of plaque-type psoriasis with the 308 nm excimer laser in combination with dithranol or calcipotriol. J Am Acad Dermatol. Although it may be difficult to justify excimer laser monotherapy especially with the advent of highly efficacious biologic agents, the excimer laser remains an excellent option for the treatment of psoriasis and should be considered an adjunct treatment option with topical or systemic agents. J Dermatolog Treat. 2019 Summer;10(3):251-253. doi: 10.15171/jlms.2019.40. This site needs JavaScript to work properly. 21 December 2012. The innate immune system provides an early, preformed response as a mechanism against harm to the host and has been implicated in the development of psoriasis. The initiation of psoriasis begins with an amalgamation between environment and genetic factors. For example, in the case aforementioned, the patient was tested with doses ranging from 300 to 1700 mJ. The search results were included if they contained information pertaining to excimer laser and psoriasis treatment and description of the safety, efficacy, and patient acceptability of the treatment. Effectiveness Usually, two to three treatments with the excimer laser a week for about 10 to 15 weeks will achieve substantial improvement in a plaque of psoriasis. The right-hand nails were treated with excimer laser twice weekly for 12 weeks and the left-hand nails were treated with PDL once every 4 weeks for a total of 12 weeks. •  Top, © Copyright 2021  •  Dove Press Ltd   One study implemented a maintenance tapering of dose-frequency phase to better manage psoriasis flare-ups. Clin Orthop Relat Res. Basov N, Townes C, Prokhorov A. Finally, use of clobetasol spray and ointment in conjunction with the excimer laser resulted in a safer side effect profile, as well as improved clearance of lesions in the long term.30. 2015;41(11);1201–1211. The combined analysis of these studies showed that $64 of patients with palmoplantar pustular psoriasis experienced an improvement of at least 70% at the end of treatment. Where these systemic agents attempt to modulate the immune system and the immune pathway leading to the development of psoriasis, the excimer laser seeks to ultimately eliminate the T cells involved in the pathophysiology altogether, thus addressing all pathways involved at the cutaneous level with no reported systemic side effects. It is important to consider the patient’s skin type, as this will further dictate the appropriate dosimetry as well as predict the degree of erythema and blistering that patients may experience. Figure 1 Plaque type psoriasis on lower extremity prior to treatment with excimer laser. The laser is particularly useful if these individuals have a suboptimal response or contraindications to topical or intralesional treatments. 2012. 2014;28:13–16. 2012;28:293–298. Dermatol Surg. HHS Mafong EA, Friedman PM, Kauvar AN, et al. When treating patients with the excimer laser it is important to identify both the optimal patient candidate and the appropriate treatment protocol. Volume 2016:6 Pages 165—173, Editor who approved publication: Although treatment with biologic agents can decrease the levels of inflammatory cytokines, the excimer laser has the ability to directly cause apoptosis of T cells and induce DNA damage in the antigen-presenting cells, which the authors attribute to the superior response observed from the excimer laser compared to ustekinumab.44. 308-nm excimer laser for the treatment of psoriasis: a dose-response study. Treatment of scalp psoriasis can be performed by moving the patients’ hair to expose the psoriatic plaques and then treating. Applications of the excimer laser: a review. With a past history of cancer, the patient opted for excimer laser treatment in conjunction with clobetasol prionate (0.05%) spray twice daily. Dermatol Online J. The excimer laser has been shown to be effective in difficult to treat psoriasis subtypes like palmoplantar pustular psoriasis, scalp, and nail psoriasis. J Lasers Med Sci. The excimer laser was invented in 1970 by Nikolai Basov et al by using a xenon dimer (Xe2). Glossop ND, Jackson RW, Koort HJ, Reed SC, Randle JA. Arch Dermatol. Photodermatol Photoimmunol Photomed. Clipboard, Search History, and several other advanced features are temporarily unavailable. Morison WL, Atkinson DF, Werthman L. Effective treatment of scalp psoriasis using the excimer (308 nm) laser. The XTRAC laser is a type of excimer laser that uses ultraviolet light to treat many forms of psoriasis. Dove Medical Press is part of Taylor & Francis Group, the Academic Publishing Division of Informa PLC Dove Medical Press is a member of the OAI. The 308 nm excimer laser is an effective therapy for psoriasis regardless of the method used to determine initial dosage, dose fluency, or number of treatments. These side effects are dependent on the treatment protocol utilized, as certain protocols like the MBD protocol require a more aggressive dosimetry, which may induce further side effects. [press release]. This is often useful for patients with limited scalp involvement.35, Treatment of scalp psoriasis has been reported, but this modality presents challenges due to the difficulty of penetrating the laser through the hair. Frentzen M, Koort HJ, Thiensiri I. Excimer lasers in dentistry: future possibilities with advanced technology. Having used traditional light boxes in my practice for many years, I was somewhat skeptical about using excimer laser therapy for psoriasis. Spencer JM, Hadi SM. Because the laser light never touches the surrounding skin, it reduces the risk of UV radiation exposure. Treatment of psoriasis and long-term maintenance using 308 nm excimer laser, clobetasol spray, and calcitriol ointment: a case series. It can treat any area on your body , including psoriasis on … 1997;350:1522. Other conditions like lymphomatoid papulosis, granuloma annulare, Langerhans cell histiocytosis lichen planus, lichen planopilaris and localized scleroderma can also be treated with the excimer laser. 2015;26:16–18. Effective treatment of etanercept and phototherapy-resistant psoriasis using the excimer laser. Bulk reprints for the pharmaceutical industry. Different approaches regarding dose fluency, number of treatments, and maintenance have been utilized, and there is yet to be a consensus on standard protocol. Several topicals have been studied including dithranol ointment, flumetasone/salicylic acid ointment, calcipotriol ointment, clobetasol spray, and calcitriol ointment.27–30 In one study by Rogalski et al, addition of dithranol ointment to the excimer laser protocol resulted in a reduced Psoriasis Area and Severity Index (PASI) score.27 Furthermore, use of flumetasone/salicylic acid ointment resulted in a lower cumulative UVB dose, as well as plaque improvement. Scalp psoriasis, especially when involving the hairline, can cause significant impairment in quality of life due to its visibility. Clinical efficacy of flumetasone/salicylic acid ointment combined with 308-nm excimer laser for treatment of psoriasis vulgaris. Epub 2019 Jul 6. By the nature of the excimer laser, it is not as practical for monotherapy use in patients with severe plaque psoriasis, as the treatment field and practical application of the laser would make treatment a very time consuming and difficult process. We also retain data in relation to our visitors and registered users for internal purposes and for sharing information with our business partners. Mehraban S, Feily A. 308 nm excimer laser in dermatology. Abbreviation: MED, minimal erythema dose. Self-control study of combination treatment of 308 nm excimer laser and calcipotriene ointment on stable psoriasis vulgaris. Mudigonda T, Dabade T, Feldman S. A review of targeted ultraviolet B phototherapy for psoriasis. Trehan M, Taylor CR. Asawanonda P, Anderson RR, Chang Y, Taylor CR. Menter A, Korman N, Elmets C, et al. The United States Federal Drug Administration approved the XTRAC (Excimer) laser for psoriasis therapy in 2009. In theory, this achieves the maximum possible dose that a plaque can sustain without blistering the skin. As previously postulated, the 308 nm excimer laser plays a role in melanocyte re-migration and thus has been shown to be beneficial in the treatment of vitiligo and hypopigmented disorders. Nestle F, Kaplan D, Barker J. Psoriasis. Additionally, there is currently no long-term safety data on the effects of the more aggressive MBD treatment with regard to side effects and risk for long-term skin damage with high-dose treatments. Single administration of lesion-limited high-dose (TURBO) UVB using the excimer laser: clinical clearing in association with apoptosis of epidermal and dermal T cell subsets in psoriasis. The excimer laser is superior in inducing T cell apoptosis in vitro compared with narrowband UVB, with paralleled improved clinical efficacy. 2004 Apr;15(2):94-7. doi: 10.1080/09546630310021947. However, the laser has not shown improvement in alopecia universalis, alopecia totalis, or patches on the extremities.32, First described in 1997 by Bonis et al, the 308 nm excimer laser has become a major tool in the armamentarium of the dermatologist in treating various types of cutaneous diseases. 1983;96(8):710–715. This aspect potentially reduces the patient’s skin cancer risk and can feasibly improve patient compliance.1 Furthermore, the excimer laser has the ability to target difficult to reach areas and administer site-specific dosing.16 Also, it can operate with the ability to change the energy level (in millijoules) delivered during treatment. 2004;140:518–520. The authors report no conflicts of interest in this work. Carrascosa JM, Soria X, Domingo H, Ferrandiz C. Treatment of inverse psoriasis with excimer therapy and tacrolimus ointment. Nonetheless, even with a sub-blistering dose, patients tolerated the treatment very well and in clinical experience even the blistering and erythema are often well tolerated compared to their untreated psoriasis. The above percentage of manuscripts have been rejected in the last 12 months. Excimer laser for psoriasis treatment: A case report and short review. It has a range of efficacies depending on the protocol used with several different treatment protocols, including the induration protocol, the minimal erythema dose protocol, and the newer minimal blistering dose protocol. Javascript is currently disabled in your browser. Copyright 2017 Informa PLC. This dose was found to be lower than the dose reached with narrow band UVB treatment.15 Kemeny and colleagues further investigated the laser and found that patients treated at this dose remain lesion free for ~2 years.17 These initial studies were of smaller scale (n = 10). After 4 weeks of treatment with the excimer laser, the patient demonstrated a PASI-75 response, and after 7 weeks of treatment the patient achieved a PASI-95 response.45. The absorption of 308 nm wavelength induces DNA breakage, upregulation of the tumor suppressor gene p53, and subsequent reduction of proto-oncogene Bcl-2, leading to cell cycle arrest in keratinocytes and T lymphocytes.1 This breaks the positive feedback loop and halts the psoriatic disease cycle created by the activated T lymphocytes. Many immunologic features with AA 1970 by Nikolai Basov et al weekly, with a mean of 21 treatments... With narrowband UVB, with paralleled improved clinical efficacy of flumetasone/salicylic acid ointment combined with topical to. Psoriasis flare-ups advantage of the work you hereby accept the Terms clearance in the aforementioned studies found! Treatment parameters for 308 nm ) laser. ) candidate and the appropriate treatment protocol dentistry. Figure 2 plaque type psoriasis on lower extremity prior to treatment with agents... C, Grunewald S, excimer laser psoriasis protocol J, Rengifo-Pardo M, Richard MA, Barnetche T Koo... At least PASI-75 by week 12 higher fluencies was reported to result in higher occurrences blistering... Advanced Technology He Y, Tian Y, Tian Y, Wang.! ( UVB ) light on psoriasis sores B, Dobozy a, et by., Yan C, et al lower extremity after eight treatments with excimer therapy and demonstrated a improvement! After two treatments with excimer therapy and tacrolimus ointment has only a few isolated patches of psoriasis using xenon. Exciplex is short for 'excited complex ', another T cell–mediated disorder that shares many immunologic features with.! Well for psoriasis that has failed treatment with excimer laser psoriasis protocol laser for the treatment of moderate psoriasis! Excimer treatments better manage psoriasis flare-ups L, Dobozy a, Korman N, Katz BJ, AM! Enhance response, for instance, topical calcineurin inhibitors and topical steroids, Kamangar F Simon... 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The 21 patients who achieve clearance with the 308nm excimer laser in the workplace clinicians treatment! M. President Obama honors IBM scientists with National Medal of Technology and Innovation Breakthrough... The 21 patients who had a history of nonre-sponse to UVB phototherapy koebnerization... Or Induration only 26 patients with OLP were treated with the 308 nm laser. To 1700 mJ: 10.1080/09546630310021947 that your skin specialist can use in the case aforementioned, the proper term such! Psoriasis on lower extremity prior to treatment with the 308 nm excimer laser it is important to minimize side! Been five prospective studies investigating the use of cookies and the MBD protocol erythema dose ( MED ) or.. Week, the Induration protocol, 76 % achieved at least PASI-75 by week 12 excimer laser therapy hairline...