But like any supplement, there is a chance that it can cause unwanted side effects. Combined use of phosphocreatine and nifedipine for treatment of patients with acute myocardial infarction. Certain studies suggest that side effects of creatine may include: Weight gain due to water retention (sometimes up to three to five pounds of weight gain in a … Effects of creatine supplementation on renal function. Poortmans JR, Francaux M. Long-term oral creatine supplementation does not impair renal function in healthy athletes. Regular monitoring is compulsory to avoid any abnormal reactions during oral creatine supplementation. However, taking higher doses of creatine seem to make muscle pain worse. Balsom PD, Soderlund K, Sjodin B, Ekblom B. Skeletal muscle metabolism during short duration high-intensity exercise: influence of creatine supplementation. View abstract. Accessed March 12, 2017. Creatine therapy in myophosphorylase deficiency (McArdle disease): a placebo-controlled crossover trial. View abstract. View abstract. View abstract. View abstract. Rae, C., Digney, A. L., McEwan, S. R., and Bates, T. C. Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial. Hoffman, J. R., Stout, J. R., Falvo, M. J., Kang, J., and Ratamess, N. A. 1997;7(2):138-143. View abstract. Muscle strength. View abstract. J Clin Pharmacol 2003;43:29-37. . Wright, G. A., Grandjean, P. W., and Pascoe, D. D. The effects of creatine loading on thermoregulation and intermittent sprint exercise performance in a hot humid environment. Diabetes. Early research shows that taking creatine by mouth daily for 5 days does not improve exercise ability in people with multiple sclerosis. Fundam Clin Pharmacol. Whitt, K. N., Ward, S. C., Deniz, K., Liu, L., Odin, J. Isbrandt, D. and von Figura, K. Cloning and sequence analysis of human guanidinoacetate N-methyltransferase cDNA. Med Sci Sports Exerc 2003;35:769-76. Short-Term Creatine Supplementation May Alleviate the Malnutrition-Inflammation Score and Lean Body Mass Loss in Hemodialysis Patients: A Pilot Randomized Placebo-Controlled Trial. View abstract. View abstract. Kendall, K. L., Smith, A. E., Graef, J. L., Fukuda, D. H., Moon, J. R., Beck, T. W., Cramer, J. T., and Stout, J. R. Effects of four weeks of high-intensity interval training and creatine supplementation on critical power and anaerobic working capacity in college-aged men. May 2, 1998. Despite numerous publications on the ergogenic effects of this naturally occurring substance, there is little information on the possible adverse effects of this supplement. 2001;33(1):61-68. Am.J Hum.Genet. Cafiero, M., Strumia, E., Pirone, S., Pacileo, S., and Santoro, R. [The efficacy of creatine phosphate in the treatment of patients with heart failure. Effect of creatine supplementation on jumping performance in elite volleyball players. View abstract. Harris RC, Soderlund K, Hultman E. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. The American College of Sports Medicine Roundtable on the physiological and health effects of oral creatine supplementation. Carbohydrate ingestion augments creatine retention during creatine feeding in humans. View abstract. COVID-19 is an emerging, rapidly evolving situation. View abstract. J Strength Cond Res. Kingsley, M., Cunningham, D., Mason, L., Kilduff, L. P., and McEneny, J. Cancer Res 1993;53:3172-8. You should not take more Amplified Creatine 189 than directed on the label to avoid gastrointestinal side effects 3 4 5. Powers, M. E., Arnold, B. L., Weltman, A. L., Perrin, D. H., Mistry, D., Kahler, D. M., Kraemer, W., and Volek, J. Creatine Supplementation Increases Total Body Water Without Altering Fluid Distribution. Cochrane.Database.Syst.Rev. Med Sci Sports Exerc 2000;32:518-25. Fatal rhabdomyolysis with bilateral gluteal, thigh, and leg compartment syndrome after the Army Physical Fitness Test. In children with this condition, taking creatine for up to 8 years seems to improve attention, language, and mental performance. 1996;6(3):222-233. Centers for Disease Control and Prevention (CDC). The influence of dietary creatine supplementation on performance during repeated bouts of maximal isokinetic cycling in man. Nausea, diarrhea, etc. J Strength.Cond.Res 2003;17(1):26-33. View abstract. Does long-term creatine supplementation impair kidney function in resistance-trained individuals consuming a high-protein diet? View abstract. View abstract. View abstract. View abstract. View abstract. View abstract. J Sports Med Phys Fitness. Effects of ingesting creatine containing supplements during training on blood lipid profiles. Aust J Sci Med Sport 1996;28:35-9. | Ann Thorac Surg 1996;61:67-75. Comparison of creatine supplementation before versus after supervised resistance training in healthy older adults. J.Strength.Cond.Res. View abstract. The effect of oral creatine supplementation on the 1000-m performance of competitive rowers. Creatine Monohydrate Side Effects You shouldn't take too much creatine at once (stick to the recommendations on the packaging or ask your doctor), it can cause diarrhea, headache, nausea, and a few other unpleasant symptoms. View abstract. J.Strength.Cond.Res. Rheumatology (Oxford) 2000;39:293-8. Am J Clin Nutr 1996;64:622-6. Shomrat, A., Weinstein, Y., and Katz, A. View abstract. Martin KJ, Chen SF, Clark GM, et al. Law, Y. L., Ong, W. S., GillianYap, T. L., Lim, S. C., and Von, Chia E. Effects of two and five days of creatine loading on muscular strength and anaerobic power in trained athletes. Creatine supplementation and resistance training in vulnerable older women: a randomized double-blind placebo-controlled clinical trial. View abstract. Toxicological Datasheet. St. Thomas' Hospital cardioplegia: enhanced protection with exogenous creatine phosphate. Verbessem, P., Lemiere, J., Eijnde, B. O., Swinnen, S., Vanhees, L., Van Leemputte, M., Hespel, P., and Dom, R. Creatine supplementation in Huntington's disease: a placebo-controlled pilot trial. The effect of longer-term creatine supplementation on elite swimming performance after an acute creatine loading. A rare, inherited disorder that causes muscle pain and cramping (McArdle disease). View abstract. Int J Sport Nutr.Exerc.Metab 2002;12(1):33-46. Tarnopolsky MA, Roy BD, MacDonald JR. A randomized, controlled trial of creatine monohydrate in patients with mitochondrial cytopathies. Tyler, T. F., Nicholas, S. J., Hershman, E. B., Glace, B. W., Mullaney, M. J., and McHugh, M. P. The effect of creatine supplementation on strength recovery after anterior cruciate ligament (ACL) reconstruction: a randomized, placebo-controlled, double-blind trial. Creatine supplementation and sprint training in cyclists: metabolic and performance effects. 1996;6(3):213-221. This site needs JavaScript to work properly. Kinugasa, R., Akima, H., Ota, A., Ohta, A., Sugiura, K., and Kuno, S. Y. 2010;28(3):388-6. The thing is, these side effects are caused by not using creatine properly and can easily be avoided. Ostojic SM, Stajer V, Vranes M, Ostojic J. Searching for a better formulation to enhance muscle bioenergetics: A randomized controlled trial of creatine nitrate plus creatinine vs. creatine nitrate vs. creatine monohydrate in healthy men. Cochrane.Database.Syst.Rev. Neurology 10-14-2003;61(7):925-930. Syrotuik, D. G. and Bell, G. J. Schulze, A., Hess, T., Wevers, R., Mayatepek, E., Bachert, P., Marescau, B., Knopp, M. V., De Deyn, P. P., Bremer, H. J., and Rating, D. Creatine deficiency syndrome caused by guanidinoacetate methyltransferase deficiency: diagnostic tools for a new inborn error of metabolism. View abstract. Willer B, Stucki G, Hoppeler H, et al. Van Bavel D, de Moraes R, Tibirica E. Effects of dietary supplementation with creatine on homocysteinemia and systemic microvascular endothelial function in individuals adhering to vegan diets. View abstract. 2011;161(21-22):519-523. Candow, D. G., Little, J. P., Chilibeck, P. D., Abeysekara, S., Zello, G. A., Kazachkov, M., Cornish, S. M., and Yu, P. H. Low-dose creatine combined with protein during resistance training in older men. 1997;7(4):330-346. Shefner JM, Cudkowicz ME, Schoenfeld D, et al. Arch Neurol 2002;59(1):97-101. Med Sci Sports Exerc. Chwalbinska-Moneta, J. Armstrong, M. J. and Miyasaki, J. M. Evidence-based guideline: pharmacologic treatment of chorea in Huntington disease: report of the guideline development subcommittee of the American Academy of Neurology. Rev Neurol. Freilinger, M., Dunkler, D., Lanator, I., Item, C. B., Muhl, A., Fowler, B., and Bodamer, O. Fact: There is no data that shows creatine causes muscle cramps or dehydration. Baldinger, R., Katzberg, H. D., and Weber, M. Treatment for cramps in amyotrophic lateral sclerosis/motor neuron disease. 2015 Sep-Oct;38(5):163-9. View abstract. View abstract. Atassi, N., Ratai, E. M., Greenblatt, D. J., Pulley, D., Zhao, Y., Bombardier, J., Wallace, S., Eckenrode, J., Cudkowicz, M., and Dibernardo, A. J Frailty Aging. Hamilton, K. L., Meyers, M. C., Skelly, W. A., and Marley, R. J. Lee, C. L., Lin, J. C., and Cheng, C. F. Effect of caffeine ingestion after creatine supplementation on intermittent high-intensity sprint performance. Br J Cancer 1999;79(2):278-285. Neurology 8-14-2001;57(3):559-560. Effect of low dose, short-term creatine supplementation on muscle power output in elite youth soccer players. Pharmacol Res 2000;41:255-64. The most common adverse effect is transient water retention in the early stages of supplementation. Leader, A., Amital, D., Rubinow, A., and Amital, H. An open-label study adding creatine monohydrate to ongoing medical regimens in patients with the fibromyalgia syndrome. View abstract. View abstract. View abstract. J Strength Cond Res. 2005;15(9):1923-1926. Volek, J. S., Mazzetti, S. A., Farquhar, W. B., Barnes, B. R., GOMEZ And AL, and Kraemer, W. J. Physiological responses to short-term exercise in the heat after creatine loading. Int J Sports Med 2001;22(8):546-552. View abstract. View abstract. J.Strength.Cond.Res. Yáñez-Silva A, Buzzachera CF, Piçarro IDC, Januario RSB, Ferreira LHB, McAnulty SR, Utter AC, Souza-Junior TP. Neurology 7-8-2003;61(1):141-142. Knott, A., Koop, U., Mielke, H., Reuschlein, K., Peters, N., Muhr, G. M., Lenz, H., Wensorra, U., Jaspers, S., Kolbe, L., Raschke, T., Stab, F., Wenck, H., and Gallinat, S. A novel treatment option for photoaged skin. View abstract. Effects of 30 days of creatine ingestion in older men. View abstract. Creatine and cyclocreatine attenuate MPTP neurotoxicity. Med Sci Sports Exerc 1999;31:236-42. Most cases that report negative side effects are a result of Med Sci Sports Exerc 1997;29(5 Suppl):S145. 2009;108(3):711-713. View abstract. View abstract. La fosfocreatina nell'infarto miocardico acuto: studio randomizzato multicentrico. So before you go all-in on taking creatine, here's what the supplement actually is, what it does, and how to avoid any of its side effects. Almeida, L. S., Rosenberg, E. H., Martinez-Munoz, C., Verhoeven, N. M., Vilarinho, L., Jakobs, C., and Salomons, G. S. Overexpression of GAMT restores GAMT activity in primary GAMT-deficient fibroblasts. Iran J Kidney Dis. Alternative perioperative anticoagulation monitoring during cardiopulmonary bypass in aprotinin-treated patients. One of the reported side effects of creatine is weight gain. Creatine ruled out in athletes' deaths. Klopstock, T., Querner, V., Schmidt, F., Gekeler, F., Walter, M., Hartard, M., Henning, M., Gasser, T., Pongratz, D., Straube, A., Dieterich, M., and Muller-Felber, W. A placebo-controlled crossover trial of creatine in mitochondrial diseases. Oral creatine supplementation and upper extremity anaerobic response in females. 2018;15(1):38. Med Sci.Sports Exerc. Grazioli I, Melzi G, and Strumia E. Multicenter controlled study of creatine phosphate in the treatment of heart failure. View abstract. View abstract. Eckerson, J. M., Stout, J. R., Moore, G. A., Stone, N. J., Iwan, K. A., Gebauer, A. N., and Ginsberg, R. Effect of creatine phosphate supplementation on anaerobic working capacity and body weight after two and six days of loading in men and women. Easton, C., Calder, A., Prior, F., Dobinson, S., I'Anson, R., MacGregor, R., Mohammad, Y., Kingsmore, D., and Pitsiladis, Y. P. The effects of a novel "fluid loading" strategy on cardiovascular and haematological responses to orthostatic stress. CONDITIONS OF USE AND IMPORTANT INFORMATION: Anomasiri, W., Sanguanrungsirikul, S., and Saichandee, P. Low dose creatine supplementation enhances sprint phase of 400 meters swimming performance. Cramer, J. T., Stout, J. R., Culbertson, J. Y., and Egan, A. D. Effects of creatine supplementation and three days of resistance training on muscle strength, power output, and neuromuscular function. Magn Reson.Med. Pastula, D. M., Moore, D. H., and Bedlack, R. S. Creatine for amyotrophic lateral sclerosis/motor neuron disease. Jahan S, Fatima A, Alam I, Ullah A, Rehman H, Afsar T, Almajwal A, Razak S. BMC Nutr. 2010;15(5):785-795. Rahimi, R. Creatine supplementation decreases oxidative DNA damage and lipid peroxidation induced by a single bout of resistance exercise. Effect of creatine supplementation on aerobic performance and anaerobic capacity in elite rowers in the course of endurance training. View abstract. View abstract. 2009;(3):CD006455. 2010;11(6):508-513. Cox, G., Mujika, I., Tumilty, D., and Burke, L. Acute creatine supplementation and performance during a field test simulating match play in elite female soccer players. Acta Physiol Scand 1995;155:387-95. J Appl Physiol 2000;88:1181-91. There haven't been any negative side effects noted in the research with creatine when using the recommended levels of supplementation. Tang G, Serfaty-Lacrosniere C, Camilo ME, et al. de Salles Painelli V, Alves VT, Ugrinowitsch C, et al. 1998 Jul 18;352(9123):234 de Guingand DL, Palmer KR, Snow RJ, Davies-Tuck ML, Ellery SJ. 2002;34(2):332-343. Anabolic Steroid Act, Public Law No. Am.J.Respir.Crit Care Med. Degussa BioActives. Are there any Side Effects of taking Creatine Monohydrate? Taking creatine by mouth daily does not seem to increase muscle mass or strength in men with muscle loss due to HIV. Javierre, C., Lizarraga, M. A., Ventura, J. L., Garrido, E., and Segura, R. Creatine supplementation does not improve physical performance in a 150 m race. -, Med Sci Sports Exerc. Vandeberghe K, Gillis N, Van Leemputte M, et al. Acute creatine loading increases fat-free mass, but does not affect blood pressure, plasma creatinine, or CK activity in men and women. Early research shows that taking creatine daily for 6 months can slightly improve symptoms in females with Rett syndrome. View abstract. Stockler, S., Isbrandt, D., Hanefeld, F., Schmidt, B., and von Figura, K. Guanidinoacetate methyltransferase deficiency: the first inborn error of creatine metabolism in man. Vandenberghe K, Van Hecke P, Van Leemputte M, and et al. Jacobs, I., Bleue, S., and Goodman, J. Creatine ingestion increases anaerobic capacity and maximum accumulated oxygen deficit. Med Sci Sports Exerc 2005;37(5):731-736. Hyperthermia and dehydration-related deaths associated with rapid weight loss in three collegiate wrestlers - North Carolina, Wisconsin, and Michigan, November-December 1997. Acta Physiol Hung. 2000;170(3):217-224. Med Sci Sports Exerc 1999;31:1108-10. View abstract. The effects of ergogenic compounds on myogenic satellite cells. Sykut-Cegielska, J., Gradowska, W., Mercimek-Mahmutoglu, S., and Stockler-Ipsiroglu, S. Biochemical and clinical characteristics of creatine deficiency syndromes. Taes, Y. E., Marescau, B., De, Vriese A., De Deyn, P. P., Schepers, E., Vanholder, R., and Delanghe, J. R. Guanidino compounds after creatine supplementation in renal failure patients and their relation to inflammatory status. Influence of creatine monohydrate ingestion on muscle metabolites and intense exercise capacity in individuals with multiple sclerosis. Effect of creatine supplementation on metabolism and performance in humans during intermittent sprint cycling. View abstract. View abstract. Int J Sports Med 2001;22(1):76-80. Chilibeck, P. D., Chrusch, M. J., Chad, K. E., Shawn, Davison K., and Burke, D. G. Creatine monohydrate and resistance training increase bone mineral content and density in older men. Balsom PD, Soderland K, Ekblom B. Creatine in humans with special reference to creatine supplementation. Med.Sci.Sports Exerc. Kristensen, C. A., Askenasy, N., Jain, R. K., and Koretsky, A. P. Creatine and cyclocreatine treatment of human colon adenocarcinoma xenografts: 31P and 1H magnetic resonance spectroscopic studies. View abstract. View abstract. 2018 Dec 13;4:41. doi: 10.1186/s40795-018-0250-y. Gastrointestinal Side Effects A severe case of diarrhea may also lead to electrolyte imbalances and dehydration. Usually, consumers do not report any adverse effects, but body mass increases. J Sports Sci 1996;14:175-9. Long-term creatine intake is beneficial to muscle performance during resistance training (abstract). Bemben, M. G., Bemben, D. A., Loftiss, D. D., and Knehans, A. W. Creatine supplementation during resistance training in college football athletes. View abstract. B., de Coo, I. F., Huijmans, J. G., Jakobs, C., van der Knaap, M. S., Salomons, G. S., and Mancini, G. M. Long-term follow-up and treatment in nine boys with X-linked creatine transporter defect. Eur J Clin Invest 1999;29:1060-5. Vitamin K2 and serum cholesterol in patients on continuous ambulatory peritoneal dialysis. View abstract. Engelhardt, M., Neumann, G., Berbalk, A., and Reuter, I. Creatine supplementation in endurance sports. Magn Reson.Imaging 2010;28(5):698-707. Kendall, R. W., Jacquemin, G., Frost, R., and Burns, S. P. Creatine supplementation for weak muscles in persons with chronic tetraplegia: a randomized double-blind placebo-controlled crossover trial. J Appl.Physiol 2003;94(5):1910-1916. When you decide to take creatine supplements, make sure it is creatine monohydrate. [Use of creatine phosphate in treatment of cardiocerebral syndrome associated with acute myocardial infarct in the aged]. View abstract. Nutrients. Clin Ter. II. View abstract. 2019;33(4):428-440. Amino Acids 2011;40(5):1369-83. Volek, J. S., Kraemer, W. J., Bush, J. Tarnopolsky, M. A. and MacLennan, D. P. Creatine monohydrate supplementation enhances high-intensity exercise performance in males and females. View abstract. Bender, A., Samtleben, W., Elstner, M., and Klopstock, T. Long-term creatine supplementation is safe in aged patients with Parkinson disease. Clin Ter. View abstract. View abstract. Vasc.Med. View abstract. Creating supplementation and lower limb strength performance: a systematic review and meta-analysis. Clin Sci (Colch) 1996;91:113-8. J Am Diet Assoc 1999;99:593-5. This creatine production occurs in the liver, pancreas and kidneys. Creatine enhances oxygen uptake and performance during alternating intensity exercise. Balsom PD, Ekblom B, Soderlund K, and et al. Kreider RB, Kalman DS, Antonio J, et al. J Sports Med Phys Fitness 2003;43(3):347-355. Ann Pharmacother 2013;47(7-8):e33. J Int Soc Sports Nutr. Willoughby, D. S. and Rosene, J. J Clin Psychiatry 2007;68:881-4. Some evidence shows that muscle strength and fatigue seem to improve after taking creatine daily for 8-16 weeks. Physiological response to exercise in the heat following creatine supplementation. O'Rourke, D. J., Ryan, S., Salomons, G., Jakobs, C., Monavari, A., and King, M. D. Guanidinoacetate methyltransferase (GAMT) deficiency: late onset of movement disorder and preserved expressive language. Gualano B, Ugrinowitsch C, Novaes RB, et al. CREATINE SUPPLEMENTATION AND SPRINT TRAINING IN CYCLISTS: METABOLIC AND PERFORMANCE EFFECTS. Medicine & Science in Sports & Exercise 1996;28(5):81. View abstract. View abstract. J Neurosci 1998;18:156-63. Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis. Rodriguez, M. C., MacDonald, J. R., Mahoney, D. J., Parise, G., Beal, M. F., and Tarnopolsky, M. A. Med Sci Sports Exerc 2001;33:183-8. Eur.J.Appl.Physiol 2009;105(6):899-908. View abstract. Kern M, Podewils LJ Vukovich M Buono MJ. Carducci, C., Santagata, S., Leuzzi, V., Carducci, C., Artiola, C., Giovanniello, T., Battini, R., and Antonozzi, I. Quantitative determination of guanidinoacetate and creatine in dried blood spot by flow injection analysis-electrospray tandem mass spectrometry. Bird, L. M., Tan, W. H., Bacino, C. A., Peters, S. U., Skinner, S. A., Anselm, I., Barbieri-Welge, R., Bauer-Carlin, A., Gentile, J. K., Glaze, D. G., Horowitz, L. T., Mohan, K. N., Nespeca, M. P., Sahoo, T., Sarco, D., Waisbren, S. E., and Beaudet, A. L. A therapeutic trial of pro-methylation dietary supplements in Angelman syndrome. Sakellaris, G., Nasis, G., Kotsiou, M., Tamiolaki, M., Charissis, G., and Evangeliou, A. Scand.J Med Sci.Sports 1998;8(5 Pt 1):247-251. View abstract. This can lead to low levels of creatine in the brain. Int J Sport Nutr. Effects of creatine supplementation on body composition, strength, and sprint performance. Available at: https://www.olympic.org/fight-against-doping. View abstract. Rawson, E. S., Stec, M. J., Frederickson, S. J., and Miles, M. P. Low-dose creatine supplementation enhances fatigue resistance in the absence of weight gain. Amyotroph.Lateral.Scler.Other Motor Neuron Disord 2000;1(suppl 4):17-20. Cooke WH, Barnes WS. View abstract. 2016 Mar 4;8(3):143. J Trauma 2002;53:761-3. Sijens, P. E., Verbruggen, K. T., Meiners, L. C., Soorani-Lunsing, R. J., Rake, J. P., and Oudkerk, M. 1H chemical shift imaging of the brain in guanidino methyltransferase deficiency, a creatine deficiency syndrome; guanidinoacetate accumulation in the gray matter. Current Therapeutic Research 1992;51(5):649-660. Wadman, R. I., Bosboom, W. M., van den Berg, L. H., Wokke, J. H., Iannaccone, S. T., and Vrancken, A. F. Drug treatment for spinal muscular atrophy types II and III. 2009;96(3):325-336. Rawson ES, Clarkson PM. Creatine Side Effects Creatine supplementation can lead to 2-4lbs of weight gain in a week – your muscles retain water in order to heighten protein synthesis (the building of muscles). Muscle breakdown. Ferraro S, Codella C, Palumbo F, et al. J R.Army Med Corps 2010;156(1):41-43. Louis, M., Lebacq, J., Poortmans, J. R., Belpaire-Dethiou, M. C., Devogelaer, J. P., Van Hecke, P., Goubel, F., and Francaux, M. Beneficial effects of creatine supplementation in dystrophic patients. Sports Med 2015;45(9):1285-94. Ostojic, S. M. and Ahmetovic, Z. Gastrointestinal distress after creatine supplementation in athletes: are side effects dose dependent? Negative Creatine Monohydrate Side Effects Like I said, there are some negative creatine monohydrate side effects. Rinsho Shinkeigaku 2004;44(10):661-666. J Sports Sci. View abstract. Nat Med 1999;5:347-50. View abstract. But creatine does not seem to improve aerobic exercise capacity, pain, sleep, quality of life, or mental function in people with fibromyalgia. View abstract. 1997 Apr;29(4):489-95 van der Merwe, J., Brooks, N. E., and Myburgh, K. H. Three weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby players. Arch Ophthalmol 1993;111:1463;discussion 1463-6. View abstract. McMorris, T., Mielcarz, G., Harris, R. C., Swain, J. P., and Howard, A. Creatine supplementation and cognitive performance in elderly individuals. View abstract. 2008;40(9):1645-1652. View abstract. J.Sports Med.Phys.Fitness 2012;52(2):165-169. View abstract. View abstract. Boos, C. J., White, S. H., Bland, S. A., and McAllister, P. D. Dietary supplements and military operations: caution is advised. Med Sci.Sports Exerc. It’s very common to appear Dev.Med.Child Neurol. View abstract. Redondo, D. R., Dowling, E. A., Graham, B. L., Almada, A. L., and Williams, M. H. The effect of oral creatine monohydrate supplementation on running velocity. J.Strength.Cond.Res. Specifically, things like muscle cramps or an upset stomach. Effects of oral creatine supplementation on muscular strength and body composition. J Sports Sci 1999;17:853-9. View abstract. J Thorac.Cardiovasc.Surg. Cochrane.Database.Syst.Rev. View abstract. Early research shows that taking creatine by mouth daily in combination with strengthening exercises improves physical functioning in postmenopausal women with knee osteoarthritis. 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